Archives for posts with tag: pharmaceutical

Your Pores: The Basics
Everybody’s got ’em — they’re the openings to our oil glands.  But whether or not you pay attention to your pores probably depends on their size.

If you don’t spend much time poring over your pores, chances are they’re small and don’t get clogged too often.  But if your pores are on the larger side, you might be dealing with one or more acne-related conditions including blackheads, whiteheads and cysts. Typically, people with oily skin tend to have enlarged pores that secrete excess oil, or sebum.  Larger pores are also more likely to get clogged with dead skin cells, dirt, and bacteria.  Dermatologists generally treat acne-related conditions with topical antimicrobials that help disinfect the skin, and topical retinoids to help unclog pores and prevent whiteheads and blackheads from forming.  For more moderate or severe cases of acne, an oral antibiotic like erythromycin, tetracycline, doxycycline, or minocycline may be prescribed.

The fact is you can’t get rid of your pores, or even shrink them, but you can cleanse and care for your skin in ways that make pores less visible.  And that includes staying out of the sun — too much sun exposure (as well as the aging process) reduces the amount of collagen in our skin, and that also causes pores to expand.

Do-It-Yourself Tactics
Try these at-home strategies and you might be able to avoid expensive dermatological procedures and spa treatments.

  • Use a pore-refining cleanser to help break up excess oil, dirt, dead skin cells, and bacteria that can clog enlarged pores.
  • Give yourself a weekly pore-purifying facial treatment.
  • Make your own deep-cleansing mask using ingredients such as honey, yogurt, or basic Fuller’s earth clay (find it at a health food store) and adding citrus, strawberries, banana, apple cider vinegar, or rosewater.
  • Exfoliate a few times a week with a store-bought or homemade scrub, or go for an exfoliating cleansing cloth. More options to try: products that contain chemical or fruit-enzyme exfoliants such as lipohydroxy acid, salicylic acid, glycolic acid, and alpha and beta hydroxy acids, all of which work to dissolve build-up in your pores.
  • Try store-bought microdermabrasion cleansing cloths and/or polishers, which work similarly but more gently than a professional microdermabrasion treatment.
  • Put your makeup to work. Products such as primers, concealers, foundation, loose mineral powder, and blotting sheets can help you maintain coverage and make large pores less visible. Just be sure to thoroughly cleanse your face at day’s end to keep pores from getting clogged with makeup residue.

Get Professional Help
If your issues are more significant, talk to your dermatologist about professional treatments such as:

  • Dermatological Facials: Many dermatologists and licensed aestheticians offer professional facials that include deep cleansing, exfoliation, steaming, extractions, massage, mask, and moisturizing.
  • Chemical Peels: A professional peel performed by a dermatologist or licensed aesthetician can remove dead skin cells, clear plugged pores, eliminate whiteheads and blackheads, correct discoloration, and generate new skin growth.
  • Microdermabrasion: During this deep-cleansing procedure, your practitioner “sands” your skin with a handheld device that shoots a spray of fine crystals onto your face and simultaneously vacuums them up. This non-invasive procedure produces instant pore-perfecting results. (Microdermabrasion is also effective at reducing the appearance of fine lines, wrinkles, creases, sun damage, and minor scars.)

A Final Word
Even though people with normal and dry skin tend to have smaller pores than those with an oily or combination complexion, they may still be susceptible to certain pore problems the cause your acne. Plus, skin type can change with age, or as a result of environmental factors, genetics, nutrition, or complications related to other health conditions.  If you’re concerned about any skin changes, talk to your dermatologist.

 

In 2005 the FDA provided a public draft guidance document to the pharmaceutical industry on how to develop drugs to treat acne vulgaris, or acne. The draft guidance document contains the FDA’s current thinking on the development of acne drugs and the methods that should be used.  Some of the guidance document information is summarized below. At the time of this writing the FDA document had not been finalized.

Types of Acne Lesions
The two major types of acne lesions are classified as non-inflammatory and inflammatory. Non-inflammatory acne lesions are more commonly known as whiteheads and blackheads. Inflammatory acne lesions include papules and pustules and are more deeply seated in the skin than the non-inflammatory lesions.

How Acne Severity Is Rated
Currently there is no standardized method for rating the severity of acne outbreaks. Several methods have been proposed, but each has its difficulties. A sample scale for rating acne severity is summarized below, from least to most severe:

  • (0)  Clear skin with no inflammatory or non-inflammatory lesions
  • (1)  Almost clear; rare non-inflammatory lesions with no more than one small inflammatory lesion
  • (2)  Mild severity; greater than Grade 1; some non-inflammatory lesions with no more than a few inflammatory lesions (papules/pustules only, no nodular lesions)
  • (3)  Moderate severity; greater than Grade 2; up to many non-inflammatory lesions and may have some inflammatory lesions, but no more than one small nodular lesion
  • (4*)  Severe; greater than Grade 3; up to many non-inflammatory and inflammatory lesions, but no more than a few nodular lesions
    (* worsening beyond Grade 4 is possible).

Acne Drug Treatment Study Groups
Pharmaceutical companies recruit participants to form test groups, which consist of people with similar symptoms who use the medication to test its effectiveness. Acne drug test groups should be large enough to be statistically significant so that any claims of success and safety can be supported. Test patients are usually recruited during their most severe acne breakouts.  Acne drug trials are recommended to be randomized, blinded, multicenter trials, and other requirements will also apply. A control or placebo group should be utilized.  Furthermore, those doing testing should recruit test populations that are representative of the age, race, gender, and geographic location of acne patients in the United States.

Determining The Success Of Acne Drug Treatments
Acne severity is rated at the beginning and end of every test. Photographic evidence and/or lesion counts may also be taken. It is proposed to measure the success of acne medications as either a success or a failure, based on one of these two methods of measuring success:

  1. Success meaning a rating of clear skin or almost clear (severity rating 0 or 1) within the test period; or
  2. Success meaning an improvement of 2 severity grades within the test period. Under this definition, a successful test subject would have a severity improvement from 4 to 2 within the test period, as an example.

The Final Decision On New Acne Drugs
Several phases of testing are recommended for proposed acne drugs. Studies must be designed to account for effects such as test dropouts. Rigorous data analysis must be performed in conformance with FDA regulations. Only acne drug test data that has been validated and undergone quality assurance testing should be submitted to the FDA for approval.  Only through a rigorous and tightly-controlled testing and analysis procedure, followed by FDA approval, can new acne drugs be made available to the public.

THE PEOPLE  BEHIND THE PRODUCT

Paul Tuffy and Chris Billis, founders of Ermis Labs, LLC and creators of CoralActives, have an inspiring amount of passion, enthusiasm, and dedication behind their story, the product, and the reason behind the company.

They were the first people to actually “test”CoralActives.  No animal testing at all. No ‘risk-free trials’ for humans. They don’t believe in animal testing, and they weren’t going to have anyone else try it before they did to make sure it worked.

“We will always be the first people to test out all of our products.  If we don’t believe in them, we definitely won’t put them out on the market for the consumer.”  So, for all you animal rights activists out there, this company has it going on!

THE STORY BEHIND THE VISION

Paul Tuffy and Chris Billis have over 30 years of combined experience in the pharmaceutical industry.  The two met at Stiefel Laboratories, (a GlaxoSmithKline company specializing in prescription skin care) while working on the dermatology marketing team.  Paul, having a background in biochemistry, and Chris, having a background in business management and marketing, came together with one vision:

To design and produce an over-the-counter skin care line that generates results equal to the more expensive and difficult to obtain prescription skin care products, while using high quality ingredients that are safe and effective.

Given their years of experience, they knew they could do it. Two years later, they have produced a new line of products under the CoralActives brand.

FROM THE BOTTOM OF THE SEA TO THE SURFACE OF THE SKIN…         CORALACTIVES – THE PRODUCTS

After much research and deliberation, Paul and Chris decided to take their venture to the depths of the sea where a unique coral grows, Sea Whip Coral.  This soft coral can be found in the Caribbean and provides a very potent and natural anti-inflammatory extract that is safe, effective and environmentally friendly.  In fact, Sea Whip Coral is a renewable resource of the sea – therefore, with every coral tip harvested in a sustainable manner, the coral experiences complete re-growth!

Due to the coral extract’s unique anti-inflammatory benefits and an abundance of clinical data supporting its use on the skin, Paul and Chris chose to use Sea Whip Extract not only in their acne products but also in their soon to be launched anti-aging line.

The CoralActives Retinol Exfoliating Cleanser is comprised of three main ingredients: encapsulated retinol (retinol that only releases as you cleanse), microbeads (the perfect size to remove dead skin but not cause irritation), and Sea Whip Extract (which helps your skin with inflammation).  Used once a day or more, the combined ingredients refresh, cleanse, and energize your skin.

The CoralActives Penetrating Acne Serum is comprised of four main ingredients: benzoyl peroxide (to kill bacteria), Sea Whip Extract (to help inflamed skin), humectants (to attract water onto your skin), and emollients (to retain the moisture on your skin).  The synergy between these ingredients creates a unique and highly effective formula that delivers results for men and women of all ages!

A BIGGER PURPOSE, AN INFINITE PURPOSE

Ermis Labs, LLC owners, Paul and Chris, are very excited about what CoralActives brings to the consumer; prescription results in over-the-counter products which stand out among other brands lining drugstore shelves.

Chris and Paul are interested in more than just offering their products for sale to the consumer.  They believe in overall skin care health and maintenance.  Education is also at top of the agenda!

“We want to provide consumers with the basics associated with good skin care to last a lifetime,” say Tuffy and Billis.

Assisting them in their campaign for good skin maintenance is Dr. Marcus Goodman of Goodman Dermatology, P.C. located in Roswell, GA.

In addition, as part of ongoing outreach efforts, consumers can count on learning more about skin care and CoralActives in middle and high schools, colleges and universities across the country.

The two entrepreneurs are also helping to create their own “mini” economic stimulus plan by helping 16 vendors across the country grow their own businesses and visions.  Paul and Chris believe in building a true partnership with every vendor and their employees.  The success of Ermis Labs, LLC also spells future success for their partners.

Paul and Chris travel to each company they work with to meet face-to-face with the people behind the scenes. It is THIS face-to-face interaction that leads to a sense of pride and ownership among those working on CoralActives. Based on their desire to help others and high quality products, we’re betting that Ermis Labs, LLC will be a success story!

IN CONCLUSION

So, I know what you’re all thinking . . . “Love the story, love Paul and Chris, now where in the heck can I get the product?!”  Haha . . . well, the product launch of CoralActives is set for mid-August.  You will be able to purchase the Retinol Cleanser & Acne Serum online at http://www.ermislabs.com for direct delivery to your home or office.

We recommend buying the Retinol Cleanser & Acne Serum together. Not only is this a financial advantage, but the products work well together to maximize the effects of clear skin.  Even if you don’t have serious acne, the serum is great for the once-in-a-while blemishes we all experience due to stress, hormones, sweat, etc.  The Retinol Cleanser can be used every day, cleansing and exfoliating all in one bottle!  So, forget the 4-step skin care set you buy every month, forget spending a vast amount of money on a gazillion different products . . . all you need is to cleanse and treat with CoralActives’ Retinol Cleanser and Acne Serum!